The Baggies' visit to the Etihad is City's last game before the FA Cup final against Wigan on Saturday and Roberto Mancini could choose to rotate his squad ahead of the Wembley showpiece.
But Clarke believes there will be no significant drop in quality even if his opposite number does make changes.
"They've got a squad of players that is packed full of internationals," said Clarke.
"Whether Roberto chooses to play his full team in preparation for the final or whether he chooses to make some changes, they will be a strong team.
"They're the champions of last season and they will want to finish well.
"We look forward to a difficult game, but it's a good game for us. Outside of our camp everybody expects us not to get a good result, but we're determined."
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