James Henry opened the scoring at Bramall Lane when his 13th-minute cross from the right evaded Blades goalkeeper Mark Howard and crept inside the far post before fellow midfielder Dave Edwards sealed the win with a close-range finish eight minutes after the restart.
Henry also hit a post with a first-half strike, while the home side went close through Stefan Scougall's early drive, which was saved by Wolves goalkeeper Carl Ikeme, and John Brayford's attempt, which was cleared off the line by Richard Stearman on the stroke of half-time.
Clough said: "I thought it was a pretty even game, I just thought they took their chances and we didn't.
"They're top of the league; that's why they're top of the league, they're a little bit more clinical, a bit more experienced than us but I thought we prepared pretty well against them for most of the game.
"We had the best chance of the game early on (Scougall's) - that could've changed it. We thought we had a couple of decent penalty appeals in the first half as well so we didn't quite get the rub of the green that maybe we've been having of late.
"It was a good measure for us as to where we want to be in 12 months' time. If you're going to lose you're unbeaten run, you might as well do it to top of the league, which we did. Over the course of the last seven, eight months they have been the best team in the division and, at times, you see why.
"We played all right, we put them under pressure but they started both halves well. But, once we settled down in the game, I thought we were a match for them at times.
"The performance was good enough. We've gone from second from bottom a couple of months ago to going toe-to-toe with top of the league."
- Sports & Recreation
- Stefan Scougall
- Richard Stearman
- John Brayford
- Bramall Lane