The National Crime Agency (NCA) named the men as Chann Sankaran, a 33-year-old Singapore national, and Krishna Sanjey Ganeshan, a 43-year-old with dual UK and Singapore nationality.
"Two men suspected of involvement in football match-fixing were charged this afternoon," the NCA said in a statement, adding that both had been remanded in custody.
"The Crown Prosecution's Organised Crime Division found sufficient evidence and was satisfied it was in the public interest to authorise charges of conspiracy to defraud."
The pair were among six people arrested earlier this week on suspicion of match-fixing. A seventh man has since been arrested and he and four others were bailed on Thursday.
The Daily Telegraph reported that the focus was on the lower leagues, with the arrests said to include three current footballers and one former Premier League player who is now an agent but still featuring in a league lower than the fifth-tier Football Conference.
The British newspaper has been investigating match-fixing around the globe for months.
The Telegraph did not specify the relevant divisions but one team is alleged to have been involved in three fixed games.
The Conference, which comprises professional and semi-professional clubs, refused to comment on Thursday over allegations some of their matches had been fixed by an overseas betting syndicate.
However, in a statement on their website (www.footballconference.co.uk), the organisation said: "The Football Conference has become aware of a story published today concerning arrests being made over alleged match-fixing.
"The Football Conference takes all matters relating to the integrity of the game very seriously but it cannot make any comment on today's story as it would be inappropriate to do so."
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