England Under-19 forward Clayton sustained a toe injury during Saturday's 1-1 draw at Leyton Orient but is expected to be passed fit to feature in the Northern Area semi-final.
Elsewhere, Alex boss Steve Davis has no other selection concerns after son Harry overcame illness to be named as a defensive option among the substitutes at Brisbane Road.
The Railwaymen overcame Doncaster on penalties in the previous round and are now three games away from a return to Wembley, where they triumphed in the npower League Two play-off final last May.
Crewe were 1-0 winners when the two sides met at Gresty Road last March, with Davis junior scoring the decisive penalty.
- Sports & Recreation
- Leyton Orient