The goalkeeper failed a late fitness test prior to last weekend's impressive 1-0 win at Exeter, a result which left the Daggers, 17th, five points clear of the drop zone in npower League Two.
Lewington has now missed the last three matches due to his back injury and should he not make it then Jordan Seabright is expected to retain his place between the posts, having displaced loanee Jonathan Miles at St James Park.
Interim boss Wayne Burnett has no new injury or suspension problems but remains without strikers Sam Williams (knee) and Josh Scott (hip).
Oxford head to Dagenham boasting a 100 per cent record in both league and cup games at Victoria Road, although the Daggers triumphed 3-2 at the Kassam Stadium earlier this season.
- Sports & Recreation