Good home form has been a key foundation in Swansea's two full seasons in the Premier League, helping them to 11th and ninth-place finishes and allowing them to take points off Manchester United, Manchester City, Chelsea, Arsenal and Liverpool.
But, since beating Newcastle just a week after last season's Capital One Cup triumph at Wembley, they have gone eight league games at the Liberty Stadium without a win.
Those fixtures have included facing Arsenal (twice), Manchester City, Tottenham, Manchester United and Liverpool, but De Guzman wants that sequence to come to an end against Gus Poyet's Black Cats.
"It will be difficult as we have lost our last two Premier League games," he said. "But it is a game we should win, we are at home and three points is mandatory.
"We have been playing well we have just lacked goals at the crucial moment, it was like that at Southampton, we created a lot of chances but didn't score, hopefully our fans can help us change that on Saturday.
"We have had a number of difficult sides to play at home, but we had good results here last season and we can do so again.
"We haven't won here for a while but beating Sunderland would set a different tone for the games ahead."
The Liberty Stadium contest will be Poyet's first game in charge of the visitors since he succeeded Paolo Di Canio.
De Guzman expects the Uruguayan's arrival to make a difference, but knows how important the game is for his own side, who are currently above the relegation zone on goal difference.
"He is very different to their previous manager so there may be a different philosophy but we have to keep playing our football and the points will come from there," said De Guzman.
"It's never easy for players or the coach coming in but it is a fresh new start for them and they will be looking forward to it and hope it is a positive move.
"But this is one of the most important weeks of our season. It will be great start if we win this week and fine motivation for our next two games against Kuban Krasnodar and West Ham.
"We have trained well and have some injured players back."
De Guzman is among those returning from injury after the midfielder suffered a groin injury which kept him out of Holland's meetings with Hungary and Turkey.
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