Nosworthy was not considered for last Friday's 2-2 draw against Crystal Palace, in which the Hornets threw away a two-goal lead, having only returned from international duty with Jamaica hours earlier.
Ekstrand also missed the clash having been forced off late on in the 2-1 win over Bolton nursing a knee injury, while Hoban is struggling with an ankle complaint.
Midfielders Ikechi Anya (hamstring) and Connor Smith (knee) as well as defender Neuton (back) remain sidelined.
Watford currently sit fourth in the npower Championship table, three points adrift of the automatic promotion places, but have lost each of their last five visits to St Andrew's.
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- Ikechi Anya