Hughes was taken off five minutes into the second half of the 2-2 draw at Bolton on Tuesday night due to a groin and pelvis problem.
Jamie Ward is expected to remain in the team for what will be his third start for the Rams in eight days and his fifth in 16 days, having played twice for Northern Ireland. Hamstring problems sidelined the forward for three months last season and Derby are trying to manage the number of games he starts in an attempt to avoid a repeat.
Midfielders Jeff Hendrick (ankle) and James Bailey (knee) and centre-halves Shaun Barker and Mark O'Brien (both knee) remain out.
- Sports & Recreation
- Jamie Ward