Fletcher was ruled out of the final eight games of the campaign after damaging ankle ligaments on international duty with Scotland in March, while the red card Sessegnon picked up at Aston Villa on Monday evening means he will sit out the clashes with Stoke, Southampton and Tottenham as the Black Cats look to end their relegation fears.
Between them, the pair have scored 18 Premier League goals this season, a little short of half the 39 the team has managed in total, and with January signing Danny Graham still to open his account, there is a genuine concern over how they are going to get themselves out of trouble.
However, Di Canio is convinced there is still strike-power within his squad as he prepares for Monday night's home clash with Stoke.
He said: "I don't talk about Stephane because he is out, I will focus my attention on my [remaining] players.
"We have enough quality to score goals to win games, especially because we play at home, which is really important.
"It means 39,000, 40,000 people are pushing for the players, which gives them extra adrenaline and motivation to give their best.
"We have quality. Danny Graham hasn't scored yet, but now I am sure the time has come when he will score because in the next few games, he will be crucial.
"We have Adam Johnson who is able of scoring. We have different ways to damage the opponent, so I am not worried, to be honest.
"I am not the kind of manager who cries - obviously I would like to have all my players available and many options."
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