But Richard Chaplow is a doubt after limping off against Birmingham on Saturday.
Winger Henry feared his season was over when he sustained a knee injury against Leeds early last month, while defender Osborne suffered a hamstring strain at Charlton three weeks ago.
But both will be looking to be involved against the Owls and prove their fitness ahead of next Saturday's FA Cup semi-final against Wigan.
However, on-loan Southampton midfielder Chaplow suffered an ankle injury in the 1-1 draw at St Andrew's and Millwall are waiting to discover the extent of the damage.
Skipper Paul Robinson remains sidelined with a groin injury.
- Sports & Recreation
- Richard Chaplow