Dyer picked up a hamstring injury in the 4-1 defeat to Manchester United, while De Guzman is still being hindered by the concussion he sustained on international duty with Holland.
Manager Michael Laudrup is likely to rotate his squad with a testing Premier League trip to Tottenham lying ahead on Sunday, with Ben Davies among those who may be rested after picking up a knock of his own against United.
- Sports & Recreation
- Manchester United
- Michael Laudrup