Centre-back Cahill has been struck down by a virus ahead of the trip to the Riverside, while right-back Azpilicueta is sidelined with discomfort in his leg.
Interim manager Rafael Benitez plans to rotate his squad in a bid to deal with the busy fixture list, meaning captain John Terry may be rested. Long-term absentee Oriol Romeu continues to miss out with a knee injury.
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