The O's reached the Southern Area final of the Johnstone's Paint Trophy by beating Yeovil on Tuesday but the victory came at a cost after Griffith was sent off and Lisbie suffered a hamstring injury.
Midfielder Griffith will serve a two-match ban for his second red card of the season while striker Lisbie could be out for longer, with the O's waiting to discover the extent of the damage.
Leon McSweeney and Martin Rowlands were rested in midweek while Lee Cook came on as a late substitute, so they will be in contention to start.
Jamie Jones continues in goal with Ryan Allsop still out of favour after turning down a new contract.
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