Arsenal loanee Afobe represented Bolton in the competition during last month's loan spell with the club, while Woolford is also ineligible having played for former club Bristol City in the third round earlier this year.
Striker Andy Keogh, who came on for Afobe in the closing stages of last weekend's 2-1 defeat to Blackpool, is in contention to replace him in the starting line-up, with Liam Feeney ready to step in for Woolford.
On-loan Derby forward Nathan Tyson remains sidelined with ankle ligament damage, while injured midfielder Chris Taylor is no closer to making a return to first-team action.
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- Liam Feeney