The big defender headed home early in the second half as victory at Pride Park for the third successive season saw Steve Bruce's team climb up to second place in the table ahead of Saturday's fixtures.
Robert Koren put the visitors in front but Michael Jacobs levelled things up on the stroke of half-time.
Hull had to survive some late pressure from the Rams but the team with the best away record in the division held on for a fourth successive win on the road.
It was only a second home defeat in the league for Nigel Clough's side and they were unfairly booed off by some supporters at the end.
A goal in each half from Sylvan Ebanks-Blake made it three wins in four matches for Wolves, who handed Michael Appleton his first defeat as Blackpool manager following a 2-1 win.
Ebanks-Blake gave Stale Solbakken's men a third minute lead - the 15th time in 23 Championship games they have opened the scoring this season.
Keeping hold of leads has been Wolves' problem and Tiago Gomes, Liverpool target Tom Ince and Wes Thomas all went close for Blackpool before the break, with the former rattling the post in the 32nd minute.
A string of excellent saves by Wanderers goalkeeper Carl Ikeme at the start of the second half preserved the advantage before Ebanks-Blake decisively netted his second from the penalty spot.
Alex Baptiste marked his 150th Blackpool appearance by pulling a goal back with 90 seconds of normal time to play but Wolves held on.
- Sports & Recreation