Nigel Pearson's previously impervious Foxes, who are now 17 points clear in the automatic promotion places - and still seven ahead of second-placed Burnley - wobbled in defence four minutes before half-time and David Goodwillie duly fired the Tangerines ahead.
But Leicester have put Ipswich, Charlton and Barnsley to the sword in recent weeks and channelled those performances to hit back with Riyad Mahrez (60), Wes Morgan (82) and substitute Kevin Phillips (87) running riot.
It was a similar story for nearest chasers Burnley, who fell behind at home to Leeds only to recover and win 2-1.
The turnaround was complete on 67 minutes as Scott Arfield hit home to help the Clarets open a 10-point gap on third-placed Derby.
The Latics showed no signs of fatigue following their surprise cup victory over Manchester City and claimed a sixth-straight league win through James McClean's brace and a goal from Leon Barnett in a 3-1 triumph at Ipswich.
Tommy Smith had opened the scoring for the East Anglian side, but the defeat leaves them in ninth place.
Nottingham Forest, however, are at risk of dropping out of the play-off places after Doncaster ground out a goalless draw at the City Ground to deny their hosts a first win in six attempts.
Jordan Rhodes returned to haunt his former club Huddersfield by hitting a hat-trick in a 4-2 victory for Blackburn.
The Scotland striker is a revered figure at the John Smith's Stadium but his treble - and a goal from Craig Conway - left the Terriers chasing their tails. Adam Hammill and Nahki Wells got on the scoresheet for the hosts.
Brighton and Watford are upwardly mobile after securing wins over Bolton and Barnsley respectively.
Will Buckley bagged a brace as the eighth-placed Seagulls ran out 2-0 victors at the Amex Stadium while Watford trio Cristian Battocchio, Troy Deeney and Alexander Merkel scored to heap more misery on relegation-threatened Barnsley, who lost 3-0.
Sheffield Wednesday are quickly forgetting about their early-season woes and took another step forward by hammering Birmingham 4-1 at Hillsborough.
Caolan Lavery notched twice with Leon Best also scoring for the Owls before an own goal from Will Packwood wounded the Blues further. Lee Novak gave Birmingham some reason to cheer with a goal 10 minutes from time.
Millwall and Charlton had the opportunity to make progress in the battle against the drop but their London derby ended goalless and Middlesbrough failed to score for the sixth game in eight during their stalemate at Bournemouth.
- Sports & Recreation
- David Goodwillie
- Riyad Mahrez