The Northern Irish midfielder was described as "touch and go" for Saturday's derby match with Torquay, before it was postponed due to a waterlogged pitch.
Doherty has not featured for the Grecians since picking up a hamstring injury the 1-0 defeat to Rotherham on November 24 but has made good progress in recent weeks and is close to making a comeback.
Experienced defender Matt Oakley was rated as doubtful ahead of the Torquay game but is expected to recover in time to face the U's, with Jimmy Keohane on hand to deputise if the former Southampton man is not passed fit.
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- Matt Oakley