The central defender missed last weekend's home defeat to Stevenage with conjunctivitis, but has trained this week and should be in contention at stadium:mk.
But fellow defender Neil Austin remains absent as he serves the third instalment of a four-game ban following two red cards this season.
Apart from that Hughes has no other injury concerns and Simon Walton will be pushing for a start after a hamstring injury restricted him to the bench against Gary Smith's side last week, while Luke James also made a substitute's return following a double hernia operation.
Pools, 10 points adrift at the foot of the table, are chasing their first win under Hughes and their first success since September 1 - a run of 20 games in all competitions.
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- Neil Austin