Former Stoke player Higginbotham, who recently signed a short-term deal until the end of the season, has started in the Blades' last two games away from Bramall Lane, while Murphy completed his permanent switch from Motherwell last week in time to make his debut in the FA Cup win at Oxford.
Manager Danny Wilson has no new injury or suspension worries, but is without defenders Matt Hill (broken jaw) and Neill Collins (fractured cheekbone) for six and eight weeks respectively, while striker Shaun Miller (knee) is out for the rest of the season.
Forward John Cofie has returned to Manchester United following the end of his half-season loan spell and midfielder David McAllister this week completed a permanent move to Shrewsbury.
Goalkeeper Mark Howard (thigh) and defender Lecsinel Jean-Francois (knee) are both back in training, but not yet ready to feature as the Blades look to climb back into the top two.
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