With the small matter of the second leg of their Champions League clash against Real Madrid on Tuesday night, it is likely Sir Alex Ferguson will rotate his squad for the visit of the Canaries.
Hughton, though, is under no illusions over the magnitude of the task which awaits his men when they run out at Old Trafford.
"It is a massive game they have on Tuesday. I think it will affect the line-up, but I don't think it will affect the quality of the line-up," said Hughton, whose side recorded a first win in 10 league games when they came from behind to beat Everton 2-1 at Carrow Road last weekend.
"Irrespective of the team they put out, we know it is going to be one of high quality.
"At this moment, they are the team who have the best quality squad in the division, there is no doubt about that.
"There is nobody who manoeuvres his squad any better than Sir Alex."
Hughton added: "We were on the back of a few draws but we managed to get that win against a very good Everton team. Scoring so late shows the resilience and determination we had to get three points."
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