Argentina, who lead the South American group and have already qualified for the 2014 finals in Brazil, host Peru in Buenos Aires on October 11 and visit Uruguay in Montevideo four days later.
Messi suffered a hamstring injury playing for Barcelona at Almeria on Saturday and is expected to be out of action for up to three weeks.
The 20-year-old Icardi, an Argentina U20 international, came through Barcelona's junior ranks before joining Sampdoria in 2011 from where he moved to Inter this season.
Sabella added Icardi to the squad he named on Friday which included Messi.
- Sports & Recreation
- Mauro Icardi
- Argentine Football Association