Jeffers sustained a hamstring injury during last weekend's 1-0 defeat to league leaders Gillingham, making way for fellow former England international James Beattie.
Alongside Beattie, Rommy Boco provides another option in attack having returned from international duty with Benin and striker Padraig Amond is edging closer to full fitness following an abductor problem.
Elsewhere, Stanley boss Leam Richardson is set to stick with the same squad that went down 1-0 at the Priestfield Stadium, with defenders Nicky Hunt (hamstring) and Mark Hughes (calf) still sidelined.
Accrington lie two points and one place above the relegation zone with six matches remaining.
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