The supporters were on their way home having seen their side beat the Hatters 2-1 in the Conference Premier to maintain their position at the top of the table.
Bedfordshire Police said that the two men were among five busloads of Kidderminster supporters.
As the coaches queued in traffic about a mile from the ground near the Mansfield Road junction an argument broke out between residents and the fans in the rear coach.
"It led to the coach being attacked," a police spokesman said. "Then some of the supporters got off to remonstrate and a fight ensued."
"Two Kidderminster fans are being treated in hospital for non life-threatening injuries, although one was stabbed twice," the spokesperson added.
Four local men have been arrested, but it is believed that the attackers did not appear to have any connection to Luton Town Football Club.
- Sports & Recreation