Skipper Shittu serves a one-match ban following his red card after the final whistle of Tuesday night's 2-1 defeat by Blackburn, and Lowry completes a three-match suspension for 15 bookings.
Mark Beevers was deputising at left-back for Lowry but is now likely to move back to centre-half in place of Shittu.
Tottenham loanee Adam Smith missed out against Rovers through illness and should return to the back four although Jack Smith, Alan Dunne or Scott Malone could also step in at left-back.
Midfield duo Sean St Ledger (ankle) and Liam Trotter (knee) will be assessed but winger Chris Taylor (groin) is definitely out.
- Sports & Recreation
- Mark Beevers