City, who also topped the previous year's list, paid £10.54 million to agents in the latest period after spending £9.66 million from October 1, 2010, to September 30, 2011.
Liverpool were in second place, having laid out £8.60 million, while the Premier league's bottom club Queens Park Rangers spent £6.82 million on agents, up from £2.5 million.
Tottenham Hotspur (£6.6 million) were fourth on the list ahead of European champions Chelsea (£6.5 million), Arsenal (£5.6 million) and West Ham United (£4.4 million) while Manchester United's spending on agents' fees fell to £3.7 million from £4.5 million.
The total of £77 million pounds spent on agents by the 20 top-flight clubs in the 12 months to September 30 rose £5.13 million from a year earlier, according to the figures on the Premier League's official website.
Promoted Southampton's outlay of £646,106 was the lowest and they were the only Premier League club to spend less than one million pounds on agents' fees.
The Premier League agreed in June 2008 that from the 2009/10 campaign each club would publish on November 30 the total amount it paid to authorised agents in the year to September 30.
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- Queens Park Rangers