The American left-hander is the leading all-time money winner at the 72-hole pro-am celebrity event, previously known as the Bob Hope Classic, and won the title in 2002 and 2004.
"We're excited about it," Humana Challenge executive director Bob Marra said during a news conference at La Quinta. "He's a two-time winner here ... and he's Phil Mickelson.
"The legacy Phil has left on our event is undeniable, his popularity among our fans is remarkable. We could not be more pleased to have him start his season with us again."
Murra said that American world number nine Brandt Snedeker, the 2012 FedExCup champion, had also confirmed he would play in the Jan. 17-20 event in the California desert.
American Mark Wilson will be back to defend his Humana Challenge title, having triumphed by two shots at La Quinta in January.
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