Fleming misses the trip to Adams Park having collected his fifth booking of the season during last weekend's FA Cup second-round defeat to Coventry.
On-loan duo Jordan Mustoe and Richard Brodie are available once more after the Wigan full-back and Crawley forward were ineligible for cup action under the terms of their deals at the Globe Arena.
Defender Will Haining is fit and fighting for a return to the starting line-up after coming back from injury to appear as a late substitute against the Sky Blues.
Forward pair Jordan Burrow and Danny Carlton (both knee) remain on the sidelines.
Jim Bentley's Shrimps head into the contest looking to end a run of four consecutive league defeats on the road, knowing 19th-placed Wycombe will draw level with them on 25 points with a victory.
- Sports & Recreation
- Richard Brodie