The Scot, who will celebrate 11 years in charge at Goodison Park in March, reaches the milestone when the Toffees travel to Bolton's Reebok Stadium in the fourth round of the FA Cup.
Moyes said: "I didn't know until this morning that it was 500 games. It's amazing that some people have got 1,000 games at one club, that is some achievement.
"Obviously 500's not a bad number when you see the way people get rid of their managers so quickly nowadays."
Moyes' tenure at Everton is highly regarded despite the lack of trophies, with the club a lot less wealthy than many of their rivals in the Barclays Premier League.
The closest they came in recent years was a run to the FA Cup final in 2009, including victory over Manchester United in the last four, but they were beaten to the trophy by Chelsea.
Moyes said: "Hopefully the real highlights are still to come, they're the ones I'm looking forward to. But I've enjoyed a lot of good times at Everton.
"My first game (against Fulham) was a great day, scoring in the opening minute. Since then we qualified for the Champions League, and in that year we had to beat Manchester United in the run-in and Newcastle, so I think that would stand out.
"And maybe the semi-final of the FA Cup, when we got to the final. Albeit we didn't win the final. There maybe haven't been enough trophies but certainly some good highlights."
- Sports & Recreation