Nugent hurt his neck in a challenge with Blackpool defender Craig Cathcart during Saturday's goalless draw at Bloomfield Road and the 14-goal striker will undergo a late fitness test.
On-loan Tottenham striker Harry Kane impressed on his debut against the Tangerines and he could make his home bow for the Foxes on Tuesday.
Matty James missed out at the weekend with a knock and the midfielder looks like being absent once more.
Ahead of the game, Leicester boss Nigel Pearson told reporters: "Knowing (Blackburn manager) Michael Appleton as I do, he'll try and make his teams difficult to beat.
"I think that's what we all try to do in all honesty, but they've got some good experience within their ranks.
"We know it will be a tough game as they've had some good results of late, but as always my main interest is how we play ourselves.
"I know that if we play to our strengths we've got a very good chance of winning the game."
- Sports & Recreation
- Craig Cathcart