The highly-rated midfielder scored Orient's opening goal in Saturday's 2-0 win over Crewe but came off during the second half with a knock to his knee, although he said on Twitter he "should be okay for Tuesday".
The O's, who are top of League One after winning all four of their matches so far, took Hull to a replay in the FA Cup last season before bowing out 2-1 in extra time at Brisbane Road.
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