Only one point separates the relegation threatened clubs at the foot of npower League Two and Argyle boss John Sheridan has received mixed injury news ahead of the match.
Defender Nelson (groin) missed the 0-0 draw with Dagenham last weekend and will sit out again while on-loan Reading striker Ugwu (ankle) is yet to play for the Pilgrims but trained with his team-mates on Thursday.
Argentine winger Andres Gurrieri could also be involved after impressing in Plymouth reserves' 2-0 win over Torquay on Tuesday.
That match saw 17-year-old striker Tyler Harvey substituted after 11 minutes after being injured in a tackle and the youth product is struggling to be fit.
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