Osman was ruled out of last week's last-gasp 1-0 win over struggling Bury due to a knee complaint but is back in contention having resumed training.
Ollie Turton misses out with a thigh problem, while veteran goalkeeper Steve Phillips is sidelined with ankle and shin complaints.
Striker Ajay Leitch-Smith is back in training following an ankle injury of his own and is unlikely to be risked at this stage by boss Steve Davis, who feels the 22-year-old will be like a new arrival when he returns.
"It's like a new signing and it will give us even more competition up front," Davis told Alex's official website.
"Lauri Dalla Valle has come in and done well and Max Clayton is looking very sharp in training.
"Ajay has been out for nine weeks so he'll need to build his fitness up, but it's great to see him back running around in training.
"But at this time of year we have a lot of games in a short space of time and you can't leave yourselves short. It's good to have a lot of options so we can change things if we need to."
- Sports & Recreation