The 30-year-old, who is the Eagles' top scorer with five league goals, is sidelined with a hamstring strain that already saw him sit out last weekend's 1-0 defeat to Southampton.
English forward Glenn Murray is set to replace Chamakh up front and lead Palace's attack at Sunderland. Pulis will have the rest of his players available for the encounter at the Stadium of Light.
Provisional squad: Speroni, Hennessey, Ward, Gabbidon, Delaney, Dann, Mariappa, Moxey, Parr, Jedinak, Dikgacoi, Bannan, Ledley, Bolasie, Ince, Puncheon, Murray, Gayle, Jerome.
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- Glenn Murray