Dave Jones' side then welcome Burnley to Hillsborough a week later before a Yorkshire derby with Leeds at Elland Road on August 17.
Another derby is scheduled for September 28 when promoted Doncaster are the visitors, while the Owls head to Barnsley on October 26 and host Huddersfield on November 23.
Wednesday hit the road over Christmas as they face Blackburn and Charlton on Boxing Day and December 29 respectively before a home clash with Blackpool on New Year's Day is followed by a visit from Leeds on January 11.
A home clash with Barnsley (February 1) and trips to Huddersfield (February 22) and Doncaster (March 22) come before Easter when the Owls head to Bournemouth on April 19 and have Charlton at home on April 21.
Their last home game of the season is against Bolton on April 26 and they finish the campaign with a trip to Ipswich the following week.