Just 78 days after being sacked by Saints, Adkins will go head-to-head with his replacement in his first home game at the Royals helm.
Anything but victory for bottom-placed Reading would be a major blow to any remaining hopes they have of staving off relegation back to the second tier.
The Berkshire outfit beat Saints to the npower Championship crown last season but the south coast side look set to have the last laugh, with back-to-back victories over Liverpool and Chelsea propelling them to a comfortable-looking 12th place.
Adkins has even suggested Saints could finish in the top 10 but Pochettino insists his side will not be getting carried away.
"In football to have confidence is really important," the Argentinian said
"Yeah, we are really confident after those wins but it is equally important to maintain a focus and we need to be mentally focused for the games ahead.
"It also happens in football than when you become overconfident you start to lose games so as well as being confident, we need to be mentally focused.
"We need to focus and we need to maintain how we felt against Chelsea and Liverpool before facing them. We felt really motivated, really confident so we need to keep that mental preparation.
"But I do think against Reading we are going to face a really tough opponent so we have been warned that we really need to be mentally focused and confident at the same time."
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