The Seagulls' 11-goal top scorer suffered an Achilles injury against Bristol City on Tuesday night and will miss the rest of the season.
With Will Hoskins also sidelined by a knee injury, boss Gus Poyet is left with only Leonardo Ulloa and Ashley Barnes as his senior frontmen.
Left-back Wayne Bridge remains a doubt with a hamstring problem but midfielders Andrew Crofts and Vicente will return to the squad.
Crofts has recovered from a hamstring injury and Vicente has been rested to build up his fitness.
Fellow midfielder Liam Bridcutt starts after receiving a surprise call-up to the Scotland squad for the World Cup qualifiers against Wales and Serbia.
- Sports & Recreation
- Leonardo Ulloa
- Will Hoskins
- Ashley Barnes