Tottenham were criticised by FIFA's medical chief among others for the decision not to substitute Lloris, yet the club's medial staff said they were "totally satisfied that he was fit to continue playing".
The France captain was rested for Thursday's Europa League win over Sheriff Tiraspol, but manager Andre Villas-Boas claimed afterwards that he would return for the Barclays Premier League clash against Newcastle.
However, Lloris was not included in the squad to face the Magpies as Brad Friedel once again deputised, with Tottenham posting a statement from Wayne Diesel, head of medical services, explaining the absence.
"We've continued to monitor Hugo all week and after discussions, Andre and the medical department have agreed to afford the player a couple more days' rest," he said.
"Hugo is naturally disappointed as he was keen to return to action however we feel this decision is in the player's best interest."
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