Talbot suffered a broken toe against Wycombe last weekend and the versatile 26-year-old is expected to be out for around a month.
Manager Paul Cook's squad has been hit by a virus, but the Liverpudlian stopped short of naming those players affected.
Brennan Dickenson has returned to Brighton following the end of his loan spell while fellow forwards Luis Boa Morte and Craig Westcarr left the club this week.
However, Cook hopes to re-sign MK Dons winger Jay O'Shea in time for Saturday's game.
O'Shea played the final match of his loan spell at Wycombe, scoring the Spireites' goal in their 2-1 defeat at Adams Park.
Cook is optimistic about his chances of bringing the Irishman back to the Proact Stadium on a permanent basis, describing the deal as "very close" to being completed.
- Sports & Recreation