Defender Eastman missed Tuesday's 2-2 draw at Coventry with the knock sustained early on in last weekend's defeat to Crewe, while striker Sears sat out of his third match in succession with a troubling knee problem.
Both are set to be absent once more at Gigg Lane while striker Jabo Ibehre also serves the final game of his three-match suspension.
Left-back Bradley Garmston shrugged off a knee complaint to start at the Ricoh Arena and should again be involved.
Manager Joe Dunne admits he may have to look at rotating one or two for what he expects will be a "toe-to-toe street fight" against Bury, with some of his side running on empty as they bid to secure League One survival.
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- Jabo Ibehre