Veteran striker Cresswell, who started out as a trainee at York 15 years ago, returned to Bootham Crescent on loan from Sheffield United last month, but his parent club have the option of recalling him after Saturday's game at Northampton.
Worthington told Press Association Sport: "Cressy is definitely with us for the trip to Northampton on Saturday and we're hopeful he'll still be here for the Southend game.
"Unless we hear otherwise from Sheffield United that should be the case."
Cresswell, 35, has started in all four of the Minstermen's games since returning to boost their npower Football League survival hopes.
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- Sheffield United