The Cottagers go into the cross-capital clash with a largely clean bill of health aside from long-term absentee Neeskens Kebano.
Lavyin Kurzawa drops out for Antonee Robinson, who is back from a ban and has been ever-present for Fulham in the league when available.
Fulham boss Silva outlined the threat Spurs can possess ahead of the Premier League game.
He told reporters: “We know how he can link really well the game when he drops and how he can be strong after with the moves from Son, Richarlison or Kulusevski, it doesn’t matter who's going to play out wide.
“Sometimes Kane needs just one touch, but the way he can hold the ball as well, he shows the capacity to make the right passes in the right moment as well.
“Of course, it's something that we are aware of and is something that we have to try to block in some moments of the game with our central defence, sometimes with the other players, to cover that space because it's something where they’re really strong.”
Fulham XI: Leno, Tete, Diop, Ream, Robinson, Palhinha, Reed, Willian, Pereira, Decordova-Reid, Mitrovic.
Subs: Rodak, Kurzawa, Adarabioyo, Wilson, Cairney, Solomon, Chalobah, James, Vinicius.