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The Hammers are top of Group H after three wins from their first three games and can secure qualification to the knockout stage with another victory in Belgium.
Goals from Craig Dawson, Issa Diop and Jarrod Bowen secured a comprehensive 3-0 win over Genk two weeks ago and there is a growing feeling that West Ham could have what it takes to go all the way in Europe.
They look a strong, slick and formidable side and Moyes will be hoping for another accomplished showing on Thursday.
Date, kick-off time and venue
Genk vs West Ham is scheduled for a 5.45pm GMT kick-off on Thursday at the Cegeka Arena in Genk, Belgium.
Where to watch Genk vs West Ham
TV channel: Tonight’s match will be televised on BT Sport 3, with coverage starting at 5.15pm.
Live stream: BT Sport subscribers will be able to watch the match online via the website or through the BT Sport app.
Genk vs West Ham team news
West Ham XI: Areola, Coufal, Dawson, Diop, Cresswell, Noble, Rice, Lanzini, Benrahma, Antonio, Masuaku
Subs: Fabianski, Zouma, Fornals, Bowen, Ogbonna, Fredericks, Soucek, Johnson, Kral, Randolph, Chesters, Baptiste.
Genk vs West Ham prediction
Belief is coursing through West Ham at the moment and they should have too much for Genk, who were dangerous in attack but hopeless at defending crosses when the two sides met last month. .
Genk 0-2 West Ham
Head to head (h2h) history and results
West Ham wins: 1
Genk wins: 0