Creamer, who won the tournament at Highland Meadows Golf Club five years ago, is seeking her first LPGA Tour victory for three years.
The former world number two, now 14th in the rankings, had a three-under 68 to go with her opening round of 66 to reel in overnight leader Alison Walshe. Also at eight-under 134 at the halfway stage was Spain's Beatriz Recari.
"You know when to step on the gas and when not to," Creamer said. "When you get a rhythm going out here it kind of takes care of itself. Experience, in any case, takes care of the issues that you have out there. It's just being confident.
"I have so much confidence out here, and the fans have been so great over the years. I kind of feel like I have a little extra bonus with them in my back pocket."
Recari had the day's lowest round with a 65 while Jacqui Concolino had a 68 to stand alone in fourth, a shot back.
Current world number one Inbee Park was lurking with intent at six-under, along with top-ranked amateur Lydia Ko and Chie Arimura.
Park, who is seeking a seventh LPGA title this season, shot a 69 in hot, difficult conditions.
"It was a tough day. I just grinded for pars," she said. "The last two birdies (on the par-5 17th and 18th holes) felt like heaven."
Defending champion So Yeon Ryu hit a 69 to end the day at five-under.
- Sports & Recreation
- Alison Walshe