Fresh from their sensational comeback victory over the Americans in Medinah last month, fellow Ryder Cup players Paul Lawrie and Miguel Angel Jimenez will also take part.
The focus returns to the Race to Dubai at for the quartet at the $2 million tournament from November 5-9.
"My record in the event isn't quite as good as I would like," said Lawrie. "But the way I've been playing this year I feel very confident of giving a good account of myself."
American Matt Kuchar, on the losing side in the most astonishing of Ryder Cup conclusions, is also set to tee it up at the event co-sanctioned by the European and Asian tours.
"I'm very excited about making my debut at the Hong Kong Open," he said. "I look forward to finding out for myself what all the buzz is about.
"The strength of the field is impressive and Rory's record in the tournament is even more impressive, so it's going to be tough to win my first European Tour title."