After being 3-0 down at half-time, the Blues were unable to rally and save their nine-game unbeaten run, as they attempted both tactical and personnel changes in the second half.
Potter’s successor Roberto De Zerbi exploited the wide areas behind Raheem Sterling and Christian Pulisic which the Blues boss admitted was a problem.
“The responsibility for those two wasn’t to defend against their wing-backs, but I understand that whenever you do something and it doesn’t work you look a bit of a fool,” Potter said at the Amex Stadium.
“That is how it is. I have to accept that, deal with that, do better, and I’ll learn. That’s the process.”
Potter added that injuries at the back have undermined his ability to select his first-choice XI in recent weeks.
He said: “It’s not about change. You need to find a way to win and perform.
“We’ve had a lot of games in October and an incredible schedule. So for different reasons, we’ve lost key players in terms of Reece [James], [Kalidou] Koulibaly, [Wesley] Fofana and [N’Golo] Kante.
“So there is a constant challenge in how to set up. We tried today and again, it can be tactical or it can be the intensity and the opponent doing what they do better. I have to analyse the game and look at how I can improve.”
It was a tough afternoon for the 47-year-old, who faced a hostile reception at his former club despite delivering their best-ever Premier League finish last season.
However, even after being booed and facing continuous chants from the home fans, he said it was not personal as he continues to wish the south coast outfit well.
“As I said before the game, I didn’t have any expectations,” he added. “I have nothing to say sorry for or apologise for.
“I did a good job, you can see the team is good. I took over when they were fourth from bottom in the Premier League and were probably the third-worst team. There is a lot of money being raised in terms of player sales and a lot of good players on the pitch.
“I hope for their sake, the next managers do as good a job and that’s brilliant for them.”
Kepa Arrizabalaga came off injured at half-time allowing Edouard Mendy to play his first minutes under his new manager.
Potter explained that the substitution was not due to the goals he conceded but because of an injury.
“He felt the bottom of his foot so I don’t know, it’s too early yet,” he concluded. “It was too bad for him to carry on. So that is disappointing for him because is he in a really good moment.”