The Warriors will have home advantage against the Championship One club, who are coached by former Wales boss Clive Griffiths, on the weekend of April 13-15.
Last year's runners-up Leeds, the reigning Super League champions, will be at home to Wakefield in one of four all-Super League ties.
The other top-flight clashes see St Helens, who gained a hat-trick of cup final victories from 2006 to 2008, take on former cup kings Widnes at the Stobart Stadium, Hull KR will host Catalan Dragons and Huddersfield will go to Hull FC.
London Broncos v Dewsbury Rams
Widnes Vikings v St Helens
Leeds Rhinos v Wakefield Trinity Wildcats
Whitehaven v Salford City Reds
Featherstone Rovers v Castleford Tigers
Hull FC v Huddersfield Giants
Wigan Warriors v North Wales Crusaders
Swinton Lions v Gateshead Thunder
Hull KR v Catalan Dragons
Bradford Bulls v Doncaster
South Wales Scorpions v Halifax
York City Knights v Sheffield Eagles
Keighley Cougars v Warrington Wolves
Leigh Centurions v Rochdale Hornets
Oldham v Barrow
Hunslet Hawks v Batley Bulldogs