Manchester City looked on course for a first league title since 1968 earlier in the season, but Sir Alex Ferguson's side are now five points clear with seven matches remaining.
An eight-point gap can be opened up over City at the top with an eighth successive league victory, although QPR will be looking to end that run at Old Trafford.
United legend and former City boss Hughes is confident the west Londoners can cause an upset in the north west, although he does not expect such a surprise in the title race.
"I think at this stage of the season there is a little bit of a sense of inevitability," the Welshman said. "United have been in this situation so many times before, City haven't and I think that can be key in this situation.
"You sense that United are looking at fixtures, taking each game on its merits and just ticking off games they have to play from now until the end of the season."