Salford opened the scoring through Jodie Broughton but the Giants hit back through Jermaine McGillvary and Michael Lawrence to lead 12-4 before Joel Moon reduced the arrears, with Daniel Holdsworth converting.
The Giants strengthened their grip on the contest with Lee's converted try, and in the second half the ruthless Giants tore into Salford, with two touchdowns in four minutes mid-way through the half killing off any hope of a Salford recovery.
A Shaun Lunt try and Lee's second created a comfortable lead, before Greg Eden added gloss to the scoreline with a try, converted by Danny Brough, who recorded a 100 per cent success rate with the boot against the Reds.
The visitors opened the scoring when Craig Hall touched down Michael Dobson's kick, before Dobson converted for a 6-0 lead.
Hull would soon respond through assistant coach Lee Radford, however, and the two sides went into the break level.
The home side took full control in the second half with tries from Kirk Yeaman, Brett Seymour and a treble from Jordan Turner in a monster 30-point haul to settle the local clash.
Danny Tickle converted every kick but one, bringing his individual points tally in the game to 12.
Francis Meli opened the scoring for the Saints but Wigan roared back and dominated the rest of the first half to open up a 12-4 lead. Centre Darrell Goulding took Thomas Leuluai's pass to cross for an equalising score and, after Pat Richards was denied a try for a foot in touch, George Carmont demonstrated his strength to reach out of a three-man tackle to touch down.
Sia Soliola crashed over for St Helens' second try, with Tom Makinson adding the goal to make it 12-10, but Tomkins added his eighth try of the season and further scores from Gareth Hock and Jeff Lima ensured Wigan claimed the derby day bragging rights.
Rangi Chase was again in dominant mood as
Chase was involved in all but one of the Tigers' six tries, with Richard Owen opening the scoring after a pass from the stand-off before Wakefield hit back through Peter Fox. Owen scorched in at the corner from another Chase pass and substitute Grant Millington then crashed in although Paul Sykes reduced the deficit to eight points before half-time with a converted try.
Steve Snitch and Brett Ferres crashed over to stretch Castleford's lead and Oliver Holmes sealed the victory, with Kirk Dixon booting his fifth conversion, but Wakefield had the last word with a breakaway try by substitute Kyle Wood which Sykes converted.
In the day's other match
Adrian Purtell and Ben Jeffries scored tries for the Bulls while Jarrod Sammut landed two goals.
Zak Hardaker's try was the only score for the Rhinos.