Jamie George has been forced to withdraw from the England training squad for the autumn internationals due to an undisclosed injury.
George, who starred in Saracens' hammering of Leicester Tigers in the Gallagher Premiership on Saturday, will be joined by fellow hooker Jack Walker and Leicester centre Guy Porter on the sidelines.
George McGuigan, the uncapped Newcastle hooker and Premiership's joint-leading try-scorer, has been called up by head coach Eddie Jones, as well as Jack Singleton, the Gloucester hooker, and Adam Radwan, the Newcastle wing. Both Radwan and McGuigan were central to the Falcons' first Premiership win of the season, as they defeated unbeaten Bristol on Friday night.
England met up on Sunday night in London for a three-day training camp ahead of their November internationals at Twickenham, when they will face Argentina, Japan, New Zealand and South Africa on consecutive weekends.
Radwan has previously won two caps for his country – both last year – scoring a hat-trick on debut against Canada. Singleton was the third-choice hooker for the 2019 Rugby World Cup campaign, which ended in a final loss to South Africa, but has not appeared for his country since that tournament.
Jones has decided against recalls for the likes of Harlequins duo Joe Marchant – who would have been a suitable replacement for Porter – and Danny Care, after admitting last week that the former had a "disappointing" summer tour of Australia and that the adding that the centre has "some work to do on his game".
The Australian has also opted against a recall for Saracens' Elliot Daly, despite his stunning performance in Saracens's victory over Leicester. Anthony Watson was originally listed as unavailable due to injury in last Monday's initial squad but, since his return for the Tigers at the StoneX Stadium on Saturday, has also been left off Jones' latest update.