New England threatened to put up a strong fight against one of the Super Bowl favourites, jumping ahead 7-3 in the first quarter after rookie Marcus Jones took a wide receiver screen 48 yards to the house.
It was just Jones' first offensive snap of his career, with the former college cornerback making a name for himself after his game-winning punt return touchdown against the New York Jets in Week 11.
But that would be the only points the Patriots would put on the board until a consolation field goal with under two minutes remaining in the fourth quarter.
The middle stages of the contest were entirely one-sided, with Josh Allen connecting on two touchdown passes in the second period to jump out to a 17-7 halftime lead, never looking back.
Allen's first touchdown was a simple one from the eight-yard line, identifying top receiver Stefon Diggs in man coverage before finding him in the back corner of the endzone.
His second was more spectacular, as he left his feet for a jump-pass near the sideline, rifling it back across his body to find Gabriel Davis for another eight-yard touchdown.
Allen completed 22 of his 33 passes for 223 yards and two touchdowns, with his only turnovers coming from a strip-sack by Josh Uche. Diggs caught seven of his nine targets for 92 yards and a score, while Devin Singletary carried 13 times for 51 yards and the game's final touchdown in the fourth quarter.